Selectins: initiators of leucocyte adhesion and signalling at the vascular wall
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چکیده
منابع مشابه
Selectins: initiators of leucocyte adhesion and signalling at the vascular wall.
The selectins are transmembrane, Ca(2+)-dependent lectins that mediate leucocyte rolling on vascular surfaces, the first adhesive step during inflammation and immune surveillance. Leucocytes express L-selectin, activated platelets express P-selectin, and activated endothelial cells express E- and P-selectin. Rolling involves force-regulated, rapidly reversible interactions of selectins with a l...
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Recent data have shown that a group of cell surface proteins, originally studied independently as lymphocyte homing receptors or as activation-induced surface proteins of platelets and/or endothelial cells (Stoolman, 1989) are structurally related. Each is an integral membrane protein with an N-terminal, C-type lectin domain followed by an EGF-like module, multiple copies of the consensus repea...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2015
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvv154